Collection
- Richard Furman and James C. Furman Collection7
- Richard L. Walker: In His Own Words1
- Robert B. Ariail Collection of Historical Astronomy2
- Robert McNair: In His Own Words1
- Ron Swain Map Collection14
- School Desegregation in the Southern and Border States53
- Senator Burnet R. Maybank Papers, 1914-19732
- Septima P. Clark Papers, ca. 1910-ca. 19904
- Sheet music from the Joseph M. Bruccoli Great War Collection3
- Skateboarding's Journey to the Olympics Oral History Collection1
- Smith and Wells Papers, 1856-19071
- South Carolina Historical Records Survey Collection1
- South Carolina LGBTQ Oral Histories, Archives, and Outreach4
- South Carolina Veterans Oral History Collection2
- South Carolina and World War II1
- South Carolina and the Civil War6
- South Caroliniana Library Map Collection26
- Specimens from the Bob Campbell Geology Museum112
- Stereoscopic Photographs1
- Strom Thurmond Collection, Mss 1009