Collection
- Confederate Spartanburg1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)109
- Cooperative Annual Reports6
- Cote Bas and Mepkin Plantations Journals, 1865-18771
- Craft and Crum Families, 1780-20071
- Dart Family Papers (1844-1945)1
- David Wyatt Aiken Papers, 1849-19761
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Deas Family Papers and Research, 1766-19761
- Delbert Claire Brandt Collection9
- Diaries106
- Downtown Greenville4
- Drayton Family Papers, 1837-186921
- Drayton Papers, 1701-20043
- E. Don Herd Photograph Collection10
- E. E. Burson Photograph Collection1
- Early California Scrapbooks1
- Edisto Island Historic Preservation Society Oral Histories4
- Edmondston-Alston Family Letters and Paper Materials, 1782-191942
- Edmondston-Alston Photograph Collection2