- Harvey Gantt and the Integration of Clemson University13
- Hemrick Nathan Salley Family Sheet Music1
- Henry Laurens papers, 1747-18604
- Henry Orion Nichols Collection13
- Henry Orion Nichols Collection 7
- Henry William Ravenel Papers, 1739-19356
- Henry William Ravenel, Plants and Planter5
- Herald-Journal Willis Collection4
- Heyward and Ferguson Family Papers, 1806-19233
- Historic Meeting Minutes of Mullins, South Carolina4
- Historic Southern Naturalists23
- History of the University of South Carolina School of Medicine - Columbia6
- Home Movies from Moving Image Research Collections14
- Horace Gilbert Smithy, Jr., M.D. Papers4
- Hunger in America3
- Hunley Artifact Collection – Personal Artifacts2
- Hutson Lee Papers, 1858-18652
- Images from the Records of the Charleston County Public Library1
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections2
- Indexes of Local History and Genealogy1