- Sanctified Holiness -- South Carolina -- Clarendon County1
- Santee A.M.E. (S. St. Paul, S.C.)1
- Santee Cooper Hydroelectric and Navigation Project--Maps1
- Sardinia (SC)--Pictorial works1
- Sardinia Presbyterian (Sardinia, S.C.)1
- Scarlatina1
- Scarlet Fever1
- Scott's Branch High School (Summerton, South Carolina) Public Schools--South Carolina--Summerton1
- Scott, Irene--Pictorial works1
- Seaborn, C.B.--Correspondence1
- Seals, James W, d. 19731
- Segregation in education--South Carolina--Clarendon County.1
- Shiloh A.M.E. (Forreston, S.C.)1
- Shuttlesworth, Fred L., 1922-20111
- Silver (S.C.) -- Religious Life and Customs1
- Simkins, Mary Modjeska Montieth, 1899-1992--Correspondence1
- Simkins, Mary Modjeska Montieth, 1899-1992--Pictorial works1
- Smith, Corine--Pictorial works1
- Society Hill A.M.E. (S. Jordan, S.C.)1
- Soil surveys--South Carolina--Clarendon County--Maps1