- South Carolina--Pamplico2
- Spence, Lee (Edward Lee)2
- Stateburg (S.C.)2
- Stock car racing2
- Sullivan’s Island (S.C.)--History2
- Summer Residential Program for Academically Superior Students (SURPASS)2
- Swimming2
- Tanglewood Plantation (Lee County, S.C.)2
- Taylors First Baptist Church (Taylors, S.C.)2
- The Gray Man (Pawley’s Island)2
- The Temple of Health (Abbeville County, S.C.)2
- Thermal Engineering Corporation (Columbia, S.C.)2
- Travis, William Barrett, 1809-18362
- Trinity Church (Columbia, S.C.)2
- USS Sumter2
- Underwater archaeology--South Carolina2
- Venus's flytrap2
- WIS News 102
- Waites, Candy Yaghjian, 1943-2
- Walker, Dora Dee, 1859-19522