- Edgefield First Baptist Church (Edgefield County, S.C.)2
- Edisto Island Baptist Church (Jasper County, S.C.)1
- Edisto River (S.C.)--Navigation1
- Education--South Carolina--Newberry--Finance1
- El Bethel Baptist Church (Cherokee County, S.C.)1
- Elim Baptist Church (Florence County, S.C.)1
- Elizabeth Baptist Church (Chesterfield County, S.C.)1
- Enon Baptist Church (Pickens County, S.C.)1
- Enslaved persons7
- Epilepsy1
- Episcopal Church--South Carolina1
- Episcopal Church. Diocese of South Carolina1
- Euhaw Baptist Church (Jasper County, S.C.)1
- Excavations (Archaeology)--South Carolina1
- Fairview Baptist Church (Spartanburg County, S.C.)1
- Fairview Baptist Church (Union County, S.C.)1
- Fever6
- First Baptist Church (Aiken County, S.C.)2
- First Baptist Church (Charleston County, S.C.)2
- First Baptist Church (Greenville County, S.C.)1