- Albea, Jane1
- Albee, Edward, 1928-20162
- Alexander, John, 1829-18981
- Ali, Muhammad, 1942-201618
- Alice Drive Baptist Church (Sumter, S.C.)2
- All Saints Episcopal Church (Cayce, S.C.)1
- All-America City Award4
- Allen University87
- Allen, James W.1
- Alvarez, Ultis, 1933-20101
- Amalgamated Clothing and Textile Workers Union1
- Ambulance service8
- Ambulances4
- American Cancer Society10
- American Institute of Architects. South Carolina Chapter3
- American Legion3
- American Legion. Richland Post No. 6 (Columbia, S.C.)21
- American Motors automobiles2
- American Revolution Bicentennial, 197613
- American Sign Language4