- Sheely, James W1
- Signious, Roy1
- Signs and signboards1
- Simkins, Modjeska Monteith, 1899-19921
- Sloan, Isabel Whaley, 1897-19911
- Sloan, John T., 1811-1895--Dwellings1
- Smith, Cora Lee1
- Smith, John1
- Smith, Rosena1
- Snakes1
- South Carolina American Revolution Bicentennial Commission1
- South Carolina Governor's Mansion (Columbia, S.C.)1
- South Carolina Penitentiary1
- South Carolina State Hospital1
- St. Peter's Catholic Church (Columbia, S.C.)1
- Stork, Robert Manning1
- Stroyer, Jacob, 1849-19081
- Student newspapers and periodicals1
- Summers Road Machinery Company1
- Sunday schools1