- Reynolds, William, 1815-1879--Pictorial works.1
- Rhett, Alfred Moore, 1829-1889--Portraits.1
- Richardson, A. H. G.1
- Ripley, Roswell Sabine, 1823-1887--Portraits.1
- Rivers--South Carolina--Columbia.1
- Roefs, Benedict1
- Sailors--United States--Correspondence.1
- Saluda Factory (Lexington County, S.C.)1
- Sam A. Cooley (Beaufort, S.C.) (Firm)--Records and correspondence.1
- Saxton, Rufus, 1824-1908.1
- Schreiner, Hermann L.2
- Scott, Winfield, 1786-18662
- Scott, Winfield, 1786-1866--Cartoons and caricatures.18
- Scott, Winfield, 1786-1866--Portraits.10
- Secession--South Carolina--Personal narratives.2
- Secession--South Carolina.5
- Secessionville, Battle of, Secessionville, S.C., 1862.4
- Seibels, Edwin G. (Edwin Granville), 1866-1954.1
- Seibels, John Jacob--Correspondence.2
- Semmes, Raphael, 1809-1877--Portraits.1