- Schools--South Carolina--Pictorial works1
- Schouboe, J. Edward1
- Scot, Emory1
- Scott, Hubert1
- Scranton (S.C.)--Maps1
- Seals, James W., d. 1973.1
- Seals, Rebecca--Pictorial works1
- Self, Ernest M.1
- Sellers (S.C.)--Maps1
- Shoe Shop1
- Sinclair, William A. (William Albert), b. 1858--Biography.1
- Skelton, Neal1
- Skyscraper1
- Slavery--South Carolina--Georgetown County1
- Slaves--South Carolina--Chesterfield County--Biography.1
- Snow1
- Society Hill (S.C.)--Maps1
- Soda Jerk1
- Soil surveys--South Carolina--Conway County--Maps1
- Soil surveys--South Carolina--Darlington County--Maps1