- Dial, Caroline Dick McKissick Belser, 1900-19942
- Dinner and dining1
- Diplomats1
- Dodson, James L., Sr., 1908-19892
- Dogs1
- Dole, Robert J., 1923-20212
- Dorn, William Jennings Bryan, 1916-20053
- Douglas, Joseph William2
- Dreher High School (Columbia, S.C.)2
- Dreher, J. Clarence (Julius Clarence), Sr., 1890-19746
- Duke, David, 1950-1
- Dwellings1
- Earle, Fort Sumter1
- Easterby, J. H. (James Harold), 1898-19601
- Eastland, James O. (James Oliver), 1904-19862
- Edens, J. Drake (James Drake), 1925-1
- Edwards, James B., 1927-20147
- Eighteenth century1
- Elections4
- Elliott, Thomas Edward, 1929-1