- Color Slides from Fort Sumter National Historical Monument2,290
- SCDOT Photographs: Properties in the Right-of-Way2,276
- Kings Mountain Nitrate Negatives2,197
- Specimens from the Bob Campbell Geology Museum2,027
- Greenville Downtown Campus (1851-1958)2,007
- John Hensel Photograph Collection2,003
- Aerial Photos of Columbia, Richland County, South Carolina (Pilot Project)1,986
- Russell Maxey Photograph Collection1,940
- Harvey Gantt and the Integration of Clemson University1,931
- President Robert C. Edwards Papers1,914
- Columbia Fire Department1,747
- Augusta Baker Papers, 1911-19981,628
- The American Revolution in South Carolina1,617
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- William A. Rosenthall Judaica Collection - Prints and Photographs1,588
- South Carolina and the Civil War1,477
- Carl Julien Collection1,471
- Isaiah DeQuincey Newman Papers1,466
- Sterling High School Yearbooks1,461
- Georgetown County Digital Library1,438