- Specimens from the Bob Campbell Geology Museum2,027
- John Hensel Photograph Collection2,003
- Aerial Photos of Columbia, Richland County, South Carolina (Pilot Project)1,986
- Russell Maxey Photograph Collection1,881
- Color Slides from Fort Sumter National Historical Monument1,871
- Greenville Downtown Campus (1851-1958)1,869
- William D. Workman, Jr. Papers Photographs1,811
- Harvey Gantt and the Integration of Clemson University1,750
- United States Marine Corps Films1,734
- President Robert C. Edwards Papers1,733
- The American Revolution in South Carolina1,617
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- William A. Rosenthall Judaica Collection - Prints and Photographs1,588
- South Carolina and the Civil War1,477
- Georgetown County Digital Library1,438
- Isaiah DeQuincey Newman Papers1,437
- YWCA of Greater Charleston, Inc., Records, 1906 - 20071,405
- John Shaw Billings Scrapbook1,371
- South Carolina State Parks Civilian Conservation Corps Architectural Plans1,359
- Furman University Faculty Travel Collections1,329