- Moth Specimens of Congaree National Park1,297
- The Furman Paladin1,282
- Sheet music from the Joseph M. Bruccoli Great War Collection1,250
- Septima P. Clark Papers, ca. 1910-ca. 19901,227
- Georgetown County Historical Survey1,216
- William Lynch Postcard Collection1,205
- The Furman Hornet1,198
- John Henry Dick Collection1,185
- South Carolina Historical Records Survey Collection1,182
- Gertrude Sanford Legendre Papers, 1844-19961,176
- Strom Thurmond Collection, Mss 1001,156
- Civic Services Committee Papers1,145
- Bernice Robinson Papers, 1920-19891,131
- Manigault's Insect Slides1,124
- E. Don Herd Photograph Collection1,112
- Harry and William Birch Collection1,098
- A. Wolfe Davidson Photographs1,082
- Works Progress Administration photograph collection: South Carolina places : 193u-194u.1,069
- South Caroliniana Library Map Collection1,063
- College of Charleston Buildings and Grounds Photograph Collection1,059