- Civic Services Committee Papers1,145
- Home Movies from Moving Image Research Collections1,135
- Bernice Robinson Papers, 1920-19891,131
- Manigault's Insect Slides1,124
- Civil War Pamphlets1,116
- E. Don Herd Photograph Collection1,112
- Harry and William Birch Collection1,098
- A. Wolfe Davidson Photographs1,082
- Works Progress Administration photograph collection: South Carolina places : 193u-194u.1,069
- College of Charleston Buildings and Grounds Photograph Collection1,059
- Midlands Memories999
- Photos from the Records of The Historic Preservation Planner, BCD-COG985
- Postcards of the Midlands944
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library940
- Thomas Benton Brooks Papers936
- Greenwood Mills Photograph Collection919
- John Henry McCray papers, 1929-1989912
- Cleveland L. Sellers, Jr. Papers, 1934 - 2003902
- Gordon R. Hennigar Pathology Museum Collection900
- This is Charleston894